If I understand this point it relates to the fallen nature of man and that without Jesus Christ they is totally irredeemable. However, I question if Depraved is the correct term to apply here? Consider: Rom 1:28 Furthermore, since they did not think it worthwhile to retain the knowledge of God, he gave them over to a depraved mind, to do what ought not to be done. Obviously, being depraved was not the starting point? And: 2Ti 3:8 Just as Jannes and Jambres opposed Moses, so also these men oppose the truth—men of depraved minds, who, as far as the faith is concerned, are rejected. It would appear, possibly, that depravity entails an active opposition to the truth? When we go out and call mankind depraved we automatically get a gut reaction to the negative. Granted, in God's Eyes all have sinned and come short of His Glory. But, are all men depraved just because of original sin? Or, do they become morally bankrupt by choice?